= Oxygen = Nitrogen = Hydrogen = Carbon = Sulfur

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Right click the model for more view options Model sourced from PubChem and rendered with JSmol.

Alternative Names

• β2-microglobulin
• B2M

Classification

• Middle Molecule

Molecular Information

• Weight: 11,000 Da [6]
• Classification: Protein

General information

• In patients on long-term hemodialysis, β2-microglobulin can aggregate into amyloid fibers that deposit in joint spaces, a disease, known as dialysis-related amyloidosis.[1] The normal value of β2 microglobulin in the blood is 0.70-1.80 mcg/mL. [3] B2M serum levels can be used as a marker for early diagnosis of cytomegalovirus infection. [4] beta 2-microglobulin (B2M) serum levels are useful in the early detection of post-transplant lymphoproliferative disease (PTLD) [5] B2M is a predictor of renal function [3]

Clinical Implications

• Beta 2 Microglobulin has been associated with the following diseases:

• Dialysis-related amyloidosis [2]

• Cytomegalovirus infection [4]

• Lymphoproliferative disease [5]

References

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531080/
• https://www.uptodate.com/contents/dialysis-related-amyloidosis
• https://emedicine.medscape.com/article/2086864-overview
• https://pubmed.ncbi.nlm.nih.gov/15194307/
• https://pubmed.ncbi.nlm.nih.gov/9067691/
• https://pubmed.ncbi.nlm.nih.gov/17684359